منابع مشابه
Excessive amounts of mu heavy chain block B-cell development.
Antigen-independent B-cell development occurs in several stages that depend on the expression of Ig heavy and light chain. We identified a line of mice that lacked mature B cells in the spleen. This mouse line carried approximately 11 copies of a transgene of the murine heavy chain constant region locus, and B-lineage cells expressed excessive amounts of the intracellular μ heavy chain. B-cell ...
متن کاملSomatic hypermutation of an immunoglobulin mu heavy chain transgene
We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing hybridomas, mutations were found in the VDJ region of the transgene. In the IgM-producing hybridomas...
متن کاملMU-chain disease in an African patient.
A new case of pt-chain disease occurring in an African patient is described. The main clinical feature was a massive splenomegaly. Contrary to five previously reported cases, this patient was not affected with chronic lymphocytic leukemia, and vacuoles were not found in the cytoplasm of the bone marrow plasma cells. A considerable increase of the plasma volume was noted without hyperviscosity. ...
متن کاملA new case of mu heavy chain disease: clinical and immunochemical studies.
A new case of mu heavy chain disease is Appreciable amounts of kappa chains described. The patient, a 48-yr-old Italian were also detected in the urine. The mu housewife, suffered from chronic lymphochain disease protein had a molecular cytic leukemia of 3 yr duration with weight of approximately 54,000 and a anemia and hepcstosplenomegaly, but no heterogeneous NH2 terminus, alanine peripheral ...
متن کاملGamma heavy chain disease simulating alpha chain disease.
A young Turkish girl presented with all the clinicopathological features of a digestive form of alpha chain disease. A gamma heavy chain disease protein, however, was found in her serum and also in the cells invading the intestinal mucosa and mesenteric lymph nodes.
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2018
ISSN: 1768-3262
DOI: 10.4267/2042/68177